Lymph node enlargement requires appropriate treatment depending on the cause; some can be treated with topical medications, while others cannot. The creams that can be used when topical medications are available include antibiotics and corticosteroids. Ointments can be used for swollen lymph nodes due to bacterial infections, immune disorders, etc. Different causes of swollen lymph nodes require different types of medications, including antibiotics and corticosteroids. Antibiotic creams include erythromycin ointment and mupirocin cream, which can promote the dissipation of inflammation and have a certain effect on the treatment of lymph node enlargement caused by bacterial infection. Corticosteroids mainly include Denadyl cream, mometasone furoate cream, clobetasol propionate cream and other drugs. Corticosteroids have anti-inflammatory and anti-immune effects and are useful in the treatment of lymph node enlargement caused by immune disorders. However, it is also important to remember that the cause of enlarged lymph nodes must be found before treatment, and that treatment does not simply involve the use of topical medications. For example, if the lymph nodes are enlarged due to tumor lesions, the use of topical medications will not produce any effect, but will delay the condition. Drugs should be used correctly under the guidance of a doctor to avoid blind use leading to adverse consequences.