Lung adenocarcinoma TP53 gene mutation should be evaluated for treatment based on the specific stage of the tumor, and the best treatment is surgical removal of the tumor. The TP53 gene, also known as P53, is an oncogene that encodes a protein with a molecular weight of 53 kDa. Mutations in this gene occur in most of all malignant tumors. The protein encoded by this gene is a transcription factor that controls the initiation of the cell cycle, and plays a decisive role from the very beginning of cell division. The TP53 gene is lowly expressed in normal cells and highly expressed in malignant tumors. Targeted drugs for TP53 are still under research and are not available for clinical use. Specific treatment options need to be evaluated by a specialist based on the patient’s specific situation to make a specific treatment plan.