Ankylosing spondylitis is a serious disease because it can worsen irreversibly and eventually become disabling. Ankylosing spondylitis is an autoimmune disease, and the symptoms get progressively worse. Treatment can only slow down the worsening of the symptoms, but it is almost impossible to reverse the symptoms, and in the final stage, it can lead to an ankylosis of the whole spine, which makes it impossible to rotate the curvature of the spine. Therefore, ankylosing spondylitis is a serious disease. Early symptoms of ankylosing spondylitis include pain in the lower back and buttock area. Low back pain occurs mainly at night and when sitting and resting, and improves with activity. As the disease progresses, the patient may experience significant limitation of spinal movement and stiffness. If not actively treated, joint damage or even disability may occur in the later stages. The goal of ankylosing spondylitis treatment is to alleviate pain and stiffness, and most patients’ condition can be well controlled with appropriate medication. Regular therapeutic physical exercise is also helpful in reducing or preventing deformities. Patients with ankylosing spondylitis must consult a rheumatologist in a timely manner, strictly follow the doctor’s instructions for treatment, and follow the doctor’s instructions for regular follow-up, which can slow down the progression of the disease and improve the patient’s quality of life.