Blackheads are a type of open acne that can arise from acne, endocrine disorders, etc. They can be helped by medication and lifestyle modifications. 1. Acne: Acne is a chronic inflammatory disease of the sebaceous gland unit of the hair follicle and is a common cause of facial blackheads. Its main manifestation is a conical pimple consistent with the hair follicle, which can be squeezed by hand to extrude the translucent sebaceous plugs that are black at the top and white at the bottom, which are the so-called blackheads. In terms of treatment, patients with mild symptoms can apply local sulfur ointment, retinoic acid cream, benzoyl peroxide ointment and other ointments to help anti-inflammatory, antiseptic and so on; patients with more serious symptoms need to take isotretinoin, doxycycline and other drugs to help treatment. 2. Endocrine disorders: when the patient has a lack of sleep, mental stress, taking a lot of hormone drugs, etc., may cause the body’s hormonal system to adjust, so that the body’s adrenaline hormone and androgen levels rise, which stimulates the skin sebaceous glands to increase secretion, resulting in an increase in blackheads and pimples. In terms of treatment, such patients need to go to a regular hospital for a face-to-face consultation, and medication to improve the situation when the original disease allows. Phentolamine can be taken to inhibit adrenaline secretion; cyproterone acetate tablets can be taken to inhibit adrenaline, androgen secretion; flutamide, nilumet and other drugs can be taken to antagonize androgen activity; at the same time, a regular work and rest routine is needed to help regulate endocrine disorders. It should be noted that the above treatments should be carried out in regular medical institutions under the guidance of physicians to avoid the occurrence of adverse reactions.