Creatinine 160μmol/L and lasts for seven or eight years belongs to a more serious situation, which may be caused by hypertension, diabetic nephropathy, chronic glomerulonephritis. 1. Hypertension: Hypertension will lead to elevated glomerular filtration pressure, and if it is not treated in time, it may continue to cause damage to the kidneys, resulting in high creatinine for a long period of time, and therefore more serious. Even some patients will have glomerulosclerosis, showing abnormal metabolic function of the kidney. 2. Diabetic nephropathy: diabetes will increase the resistance of small arteries in the glomerulus, resulting in high glomerular filtration state, causing high creatinine level. A high creatinine level lasting for seven or eight years indicates that the kidney function has been damaged, so it is a more serious situation. 3. Chronic glomerulonephritis: this disease will cause the glomerular filtration rate to increase, resulting in high creatinine. And the creatinine level of patients with chronic glomerulonephritis usually can’t return to normal, and can only slow down the damage to the kidneys through therapeutic means. This disease is more harmful to the human body, and the condition is likely to develop into chronic renal failure in the late stage, so it is a more serious condition. To summarize, creatinine has been at 160μmol/L for seven or eight years, you should seek medical treatment as soon as possible to find out the cause of the disease and actively treat it to avoid the development of the disease.