Hyperacidity after pancreaticoduodenal surgery is treated clinically with gastric acid neutralizing drugs and proton pump inhibitors. The medication should be used according to the doctor’s prescription. Under normal circumstances, when gastric juice is secreted excessively, the small intestine mucosa will secrete gastrointestinal inhibitors (glucagon, cholecystokinin, gastric inhibitory peptide, etc.) to inhibit gastric juice secretion. When the pancreaticoduodenum is removed, gastric juice secretion cannot be regulated by negative feedback and gastric juice is secreted excessively. Gastric acid neutralizers, such as sodium bicarbonate, can be used when gastric acid secretion is excessive, and the adverse effects of this medication are belching (hiccups), secondary increase in gastric acid secretion, gastric pain and distension, edema, elevated blood pressure, and alkalosis. It is contraindicated in people with restricted sodium intake and in people who are allergic to those using urotropin. Proton pump inhibitor drugs, such as omeprazole. Adverse reactions to this class of drugs are headache, abdominal pain, constipation, diarrhea, flatulence, nausea and vomiting. This class of drugs should not be combined with nelfinavir and rilpivirine and is contraindicated in allergic individuals. Patients with hyperacidity after pancreaticoduodenal surgery should be seen promptly and treated aggressively.