The standard of mannitol drip rate depends on the disease being treated, the type of disease being treated is different, the drip rate and dosage of the drug used is also different. The usual amount of mannitol adults diuretic is the usual amount of 1~2g/kg according to body weight, with 20% solution 250ml intravenous drip, adjust the dose to maintain the urine output at 30~50ml per hour. Mannitol for the treatment of cerebral edema, intracranial hypertension and glaucoma can be 0.25~2g/kg according to body weight, formulated as 15%~25% concentration in 30~60 minutes intravenous drip; when the patient’s physique is weak, the use of the dosage should be reduced to 0.5g/kg, and at the same time closely monitor the vital signs. Mannitol is used to identify pre-renal oliguria and renal oliguria, it can be injected intravenously at a concentration of 20% over 3~5 minutes at 0.2g/kg of body weight; if the hourly urine output is still less than 30~50ml after 2~3 hours of medication, it should be tried again at most. When Mannitol is used for the prevention of acute tubular necrosis, 12.5~25g is given first and recommended to be administered intravenously within 10 minutes; if there are no special circumstances, another 50g can be given intravenously within 1 hour; if the urine output can be maintained at more than 50 ml per hour, 5% solution can be continued to be applied for intravenous drip; if it is ineffective, the drug can be stopped immediately. When mannitol is used in the treatment of poisoning by drugs or poisons, it is recommended to apply 50g of the drug in 20% solution IV and adjust the dose to maintain the urine output at 100-500ml per hour. The use of mannitol may cause adverse reactions such as water and electrolyte disorders, chills, fever, etc. It is contraindicated for those who are allergic to the product. The drug needs to be used rationally under the guidance of a doctor.