At present, the better and safer antidepressants are vortioxetine and bupropion, and the first-line antidepressants are selective 5-hydroxytryptamine reuptake inhibitors, such as sertraline, fluoxetine, paroxetine, citalopram, fluvoxamine, and citalopram-like structure drugs, such as escitalopram, which are safer and have a faster onset of action, generally taking the drug for two weeks to have a significant These drugs are safer and have a quicker onset of action, with obvious effects within two weeks of taking the drug, with fewer side effects and higher tolerability by patients. You can also take dual-channel drugs, such as duloxetine, venlafaxine, etc. The most important side effects of these drugs are gastrointestinal side effects, such as nausea, vomiting, dry mouth, bitter mouth, as well as upper abdominal discomfort and decreased appetite. Therefore, there is no safest or best antidepressant drug, but only the most suitable antidepressant drug for the patient’s individual condition, so we must analyze the specific situation and choose the right drug for the patient’s condition.