Neonatal sepsis refers to a systemic inflammatory reaction caused by pathogens that invade the circulation of newborns and grow, multiply, and produce toxins. Early stage of the disease may present with poor spirit, poor appetite, weakened crying, and unstable body temperature. Faster development of the disease, can quickly appear mental depression, lethargy, do not eat, do not cry, do not move, poor color and other manifestations. Able-bodied newborns often have fever, while frail and preterm infants often do not have elevated temperatures, and can have the following more specific manifestations: 1. Jaundice: delayed subsidence of jaundice or recurrence of jaundice with sudden aggravation; 2. Hepatomegaly and splenomegaly: often seen in the footplate; 3. Hemorrhagic tendency: ecchymosis, petechiae, and symptoms of DIC can be seen; 4. Signs of shock: marbling of the skin, thin pulse, scanty urine, closed urine, and a blood pressure of < 4-6KPa; 5, others: abdominal distension, toxic intestinal paralysis, can be complicated by pneumonia, meningitis, but also osteomyelitis, septic arthritis. Deep abscess, especially the infection of Staphylococcus aureus, combined with urinary tract infection, mostly due to gram-negative bacilli. Treatment of neonatal sepsis consists mainly of anti-infective therapy and supportive therapy.