Early symptoms of patients with sublingual gland tumor are not obvious, and tongue pain and paralysis of tongue muscle can appear in middle and late stages. 1. Tumor of sublingual gland is relatively rare, and if it occurs, more than 90% of it is malignant. Adenoid cystic carcinoma is the most malignant tumor, followed by mucoepidermoid carcinoma and adenocarcinoma. 2. Malignant tumor of sublingual gland is not easy to be detected by patients in early stage, and sometimes it is found during oral examination. In the middle and late stages, patients may have tongue pain or numbness on one side of the tongue. When palpating the sublingual area with both hands, if there are hard nodules instead of submandibular gland duct stones, the tumor should be considered. Those involving the lingual nerve have tongue numbness and tongue pain, and those involving the hypoglossal nerve have paralysis of the tongue muscle on the affected side. When patients have the above symptoms, they should go to the hospital in time, and standardize the treatment under the doctor’s guidance to avoid aggravation of the condition.