High serum γ-glutamyltransferase may be due to physiologic or pathologic reasons, and may be treated with lifestyle modification, antitoxic therapy and hepatoprotective therapy, respectively. 1. Physiological high serum γ-glutamyltransferase may be related to overwork, staying up late, overeating and other bad lifestyle, need to pay attention to rest, diet, quit bad habits, usually without special treatment can be relieved by themselves. 2. Pathologic high serum gamma-glutamyl transferase may be related to alcoholic liver disease, drug liver injury, biliary tract obstruction disease, viral hepatitis. (1) Alcoholic liver disease due to long-term alcohol consumption leads to alcoholic liver damage, the need for timely cessation of alcohol and treatment of alcoholic liver disease, the general glutamyltransferase will then decline. (2) Drug liver injury due to long-term use of certain liver-damaging drugs caused by liver damage, need to change the drug or stop the drug, usually glutamyl transferase will drop. (3) Biliary tract obstruction disease is common in gallbladder stones, biliary tract obstruction, which induces a large increase in serum γ-glutamyltransferase, and generally requires surgical treatment, and the general glutamyltransferase will decrease after treatment. (4) The most common viral hepatitis is viral hepatitis B, generally need to apply lamivudine, entecavir and so on for antiviral treatment, on the basis of the application of silymarin, glucuronolactone and other non-specific hepatoprotective drugs, after the treatment of the improvement of the general glutamyltransferase will then decline. If the phenomenon of high serum gamma-glutamyltransferase occurs, it is necessary to go to the regular hospital in time, and the doctor will formulate an individualized treatment plan according to the specific situation, so as not to delay the condition.