Megaloblastic anemia is an anemia due to the lack of folic acid and vitamin B leading to deoxyribonucleic acid synthesis disorders, the common causes are as follows: 1, malnutritional anemia, gastric absorption disorders, acute hemolysis: due to the body’s need for a large amount of folic acid and vitamin B, if you can’t give a sufficient amount of it, it will be macrocytic anemia, which will be manifested as megaloblastic anemia. The causes of megaloblastic anemia are more, it needs to be diagnosed and treated under the guidance of doctors according to the specific conditions of patients to be more scientific; 2, lack of internal factor: it can lead to refractory anemia or pernicious anemia, it may need to be treated accordingly against the antibody of the internal factor, and it needs to ask the gastroenterologist to guide the treatment in order to correct the anemia well. Patients can not because of the large red blood cell volume, it is considered megaloblastic anemia, and supplement folic acid and vitamin B. 3, other causes: anemia caused by partiality, in the diet should pay attention to more folic acid and vitamin B foods, for the relief of mild anemia has some benefits. However, for patients with moderate or severe anemia, blood transfusion may be needed for symptomatic supportive treatment.