Behind almost every good medicine, there is a wonderful story. The development of Astragalus capsule, which is currently the best Chinese medicine for coronary heart disease, also has a story. According to the “Kangxi Qi Jue Jue” record, Kangxi 56 years in the spring and summer, Kangxi Emperor gradually feel weak, palpitations, palpitations, heartbeat when the face suddenly changed, there are knots in the chest, two breast in the pain. The imperial physician believes that this is phlegm and stagnation, paralysis of the heart veins, Qi deficiency and blood stasis, heart loss of nourishment, “chest paralysis”, is a “deficiency of the real” evidence, so the Kangxi Emperor was advised to take long-term with the Qi and blood, stasis and pain relief effect of ” The “Heart Returning Formula”. According to modern medicine, the Kangxi Emperor had coronary heart disease, and because the Kangxi Emperor was old and frail at the time of the onset of critical condition, in the year when heart surgery could not be performed, it was incurable. But in the “back to the heart of the formula” under the conditioning, the Kangxi Emperor continued to live for another five years, until Kangxi died in the sixty-first year. Nowadays, with the rapid development of the economy and the gradual change of people’s lifestyle, the incidence of cardiovascular diseases, represented by coronary heart disease, is rapidly increasing and has become the number one killer of people’s health. Therefore, the prevention and treatment of coronary heart disease has become one of the important issues in the medical field. In response to this trend, Henan Xinyi Pharmaceutical started to research and develop proprietary Chinese medicine for the treatment of coronary heart disease at the end of 1980s, in cooperation with relevant experts. They went through a large number of medical books, and this passage in “Kangxi Qijiu” caught their attention. Finally, with the unremitting efforts of the R&D experts, Henan Xinyi Pharmaceutical developed Shanhaidan Capsules on the basis of Kangxi’s “Heart Return Formula”. After the product was rebuilt and the classic was reborn, Shanhaidan capsule was marketed and quickly sold well throughout the country. However, during the monitoring of side effects, Henan Xinyi Pharmaceutical found that there were some defects in the formula of Shanhaidan Capsules, and some patients had side effects such as red face and dry mouth after taking it because of its warming nature. In response to these defects, Henan Xinyi Pharmaceuticals hired Professor Shang Qichang, a famous doctor in the Central Plains and former president of Henan College of Traditional Chinese Medicine, to preside over the “secondary development” of Shanhaidan Capsules. Based on the formula of Shanhaidan Capsules, Prof. Shang abandoned the formula of “Lost Laughter San” in the Song Dynasty’s “Taiping Huimin and Pharmaceutical Bureau” and “Bao Yuan Tang” in the Ming Dynasty’s “Jing Yue Quan Shu”, and finally developed a more reasonable formula of Shanhaidan improved product –Astragalus Capsules. In addition to retaining the healing effect of Shanhai Dan, Astragalus capsule also has better nourishing and moistening effect, which not only avoids “red face and dry mouth”, but also has more prominent health benefits. However, due to the large formula of Astragalus capsule and the preparation process at that time, patients had to take 5 capsules of Zero each time, which was inconvenient to take. In 2003, Henan Xinyi Pharmaceutical’s refined Astragalus capsule preparation method got a breakthrough; in 2006, Astragalus capsule got the invention patent certificate issued by the State Intellectual Property Office; in 2008, the second generation of Astragalus capsule got the new drug approval certificate from the State Food and Drug Administration. Due to the advanced Chinese medicine preparation methods such as “secondary alcohol extraction”, “secondary water extraction” and “distillation extraction”, the concentration of bioactive substances in the second generation of refined Astragalus capsules has increased The concentration of bioactive substances in the second generation of refined Astragalus capsule has increased nearly three times. The weight of the capsule has been reduced by 64% while the active ingredients remain the same, and the patient only needs to take 3 capsules of No.1 each time, which means the compliance of the medicine is greatly improved. With a reasonable scientific formula and modern advanced preparation process, Astragalus capsule brings a new choice for patients with coronary heart disease. Clinically, Astragalus Capsules features dual effect of treatment and tonicity, which not only relieves short-term symptoms, but also prevents and reduces the incidence of cardiovascular events by tonifying the patient’s constitution through the effect of its tonic herbal medicine, thus making it unique among similar proprietary Chinese medicines. Modern medicine believes that coronary angina is caused by atherosclerosis of the coronary arteries, arterial spasm or thrombosis in the diseased arteries, resulting in severe narrowing or blockage of the arteries, leading to acute ischemia. The disease belongs to the category of “chest paralysis” and “heart pain” in Chinese medicine, and its pathology is characterized by a mixture of deficiency and actuality, or mainly by actual evidence, or by deficiency and actual symptoms. But regardless of the deficiency and actual evidence, can lead to Qi and blood stagnation, does not pass then pain, as the saying goes, “qi flow is blood flow, qi stagnation is blood stasis”, “qi is the handsome of blood, blood is the mother of qi”. Astragalus capsule is made of Astragalus, Ginseng, Panax ginseng and leech, which can benefit Qi and invigorate blood, resolve blood stasis and relieve pain. The drug is formulated according to the principles of monarch, subject, adjuvant and ambassador. In the formula, Astragalus and Salvia are used as the monarchs. In this formula, Astragalus is used to nourish the Qi of the spleen and stomach, so that the Qi can flourish to promote the flow of blood and eliminate blood stasis without harming the righteousness; Dan Shen has the effect of invigorating blood and resolving blood stasis, so it can be combined with Astragalus to benefit the Qi and invigorate blood, which is complementary to both the symptoms and the root cause. Ginseng and Panax notoginseng are used as the subject herbs in this formula. Ginseng strengthens the spleen and enhances Qi, which can help Astragalus to replenish Qi; Panax notoginseng invigorates blood circulation and relieves pain, which can help Dan Shen invigorate blood circulation and resolve blood stasis. Poria, Leech, Safflower, Scutellaria, Pueraria lobata, Radix et Rhizoma Ginseng and Radix et Rhizoma Polygoni are used as adjuvants in this formula. In order to enhance the power of the ruler and subject medicine to benefit the qi and blood, the formula with Poria, to benefit the qi and strengthen the spleen; with leech, safflower, to invigorate the blood and resolve blood stasis, pass through the veins to relieve pain. Because astragalus and panax notoginseng are warm and dry products, easy to dry and hurt Yin, and leeches and other blood stasis products and easy to deplete Yin and blood, plus the stagnation of blood, heat, so it should be combined with nourishing Yin and clearing heat products. According to the “Compendium of Materia Medica”, “Scutellaria baicalensis is cold and bitter, bitter enters the heart, cold overcomes heat, and diarrhea the heart fire”, using Scutellaria baicalensis can directly reach the disease, preventing warmth and dryness from consuming qi and injuring yin; there is also heat clearing and nourishing yin, relieving heat and generating fluid, Ge Gen and Xuan Shen to help nourish yin and generate fluid; Shou Wu is bitter, sweet and slightly warm, good at nourishing essence and blood. The above medicines used together can enhance the power of the ruler and subject medicine to benefit Qi and invigorate Blood, and also clear heat to nourish Yin and generate fluid, so that Qi and Blood can be replenished and Blood stasis can be removed without other diseases. Glycyrrhiza glabra is used as the herb to harmonize all the medicines. The combination of all the herbs together can benefit Qi and blood, resolve blood stasis and relieve pain, dispel evil without harming the righteousness, support the righteousness without being attached to the evilness, dispel blood stasis and open the ligaments, all the symptoms will be cured. Animal experimental studies have proved that Astragalus capsule can significantly reduce myocardial oxygen consumption and coronary resistance, reduce the degree and extent of myocardial ischemia, and increase cardiac beat volume and coronary blood flow, thus improving cardiac function and protecting myocardial ischemia and hypoxia. According to the results of observation and analysis, the drug has obvious relief effect on angina pectoris and accompanying symptoms of coronary heart disease, and has no toxic side effects on liver and kidney function and hematopoietic system. According to the analysis of Chinese medicine, Qixin capsule is suitable for the treatment of patients with coronary heart disease of Qi deficiency and blood stasis type and heart and kidney Yang deficiency type, especially for patients with myocardial infarction combined with cardiac insufficiency after coronary artery bypass grafting.