Anal plugs of antipyretic drugs can have a fever-reducing effect, but it also has many adverse reactions, which may vary depending on the dose of anal plugs of drugs. Anal plugs of drugs to reduce fever, mainly through the skin sweating to play a role in lowering body temperature. A moderate amount of sweating can play a cooling effect, but too much sweating may lead to electrolyte disorders, general fatigue and weakness, and even hypotension and shock, requiring more water and intravenous rehydration to replenish the body’s fluids. The dosage must be mastered when applying anal plugs, and should be tried only when general conventional cooling methods are ineffective and when the body temperature exceeds 39 degrees or more. It is safer to use the medication under the guidance of a doctor, and it is not recommended to apply it at will. Anal plug of antipyretic suppository drugs, mostly non-steroidal anti-inflammatory drugs, it can also play a good role in pain relief.