1.Age of first birth 35 years or older. 2.Unmaternal 3.Age of menarche under 12 years old 4.Age of amenorrhea over 55 years old 5.Obesity 6.Long-term oral sex hormones 7.Family history of breast cancer 8.Patients with long-term benign breast disease 9.Long-term high energy and high fat diet 10.Adolescents who have been exposed to ionizing radiation 11.Long-term smoking and alcohol consumption 12.Long-term marital disagreement 13.Divorce and widowhood leading to depression