Kidney cancer is not sensitive to chemotherapy. Interventional treatment of kidney cancer as a local in situ inactivation method has been greatly developed in recent years. Small incision surgery can be combined with argon helium knife to remove kidney cancer, and percutaneous puncture cryoablation under the guidance of laparoscopy, B-ultrasound or CT can also be used to treat kidney cancer. 1. Indications for percutaneous percutaneous cryoablation of renal cancer Substantial renal masses can be treated by ultrasound-guided cryoablation after the diagnosis is confirmed by fine needle aspiration cytological examination. The following conditions are particularly suitable: (1) kidney cancer that cannot tolerate surgical resection; (2) those who are not suitable for surgery or refuse surgery because of the combination of proximal metastasis and other diseases; (3) those who have huge masses in the kidney and have failed radiotherapy and chemotherapy; (4) those who have tumors on both sides. Treatment method: The patient should be in prone or lateral position, and the puncture should be performed at the place where the tumor is most clearly shown. Ultrasound can be used to monitor the freezing effect during argon helium knife freezing, or CT scan can be performed immediately after freezing to observe the treatment effect. CT scan after Ar-He knife shows that the density of the tumor is reduced. 2. Intraoperative cryotherapy for renal cancer Indications: (1) renal tumors whose basic renal function cannot withstand conventional surgical resection; (2) huge intrarenal masses who have failed radiotherapy and chemotherapy. The surgical method is the same as surgical resection of kidney cancer. Tumors that can be removed surgically should be removed as much as possible. For kidney cancer that cannot be surgically resected, the freezing plan can be determined according to preoperative CT, MRI, B ultrasound, etc. The freezing knife can be inserted directly into the tumor, or the freezing needle can be inserted under the guidance of B ultrasound, and a thermometric probe can be placed between the tumor and normal kidney tissue to implement 2 cycles of freezing treatment. Intraoperative and postoperative tests were strictly performed with ultrasound. There was no bleeding during the procedure and no complications at the 3-month postoperative follow-up. The frozen kidney tissue underwent coagulative necrosis and a clear zone of separation from normal tissue, demonstrating that cryodestruction can be effective against human kidney tumors and the extent of freezing can reach the edge of surgical treatment. Argon helium cryosurgery for renal tumor is considered a new treatment method in the current renal preservation surgery technique. 3.Small incision or laparoscopic-guided argon helium knife for kidney cancer The application of small incision or laparoscopic-guided percutaneous puncture targeted cryotherapy for kidney tumors is safe and effective, which can reduce the damage to normal kidney parenchyma, significantly reduce postoperative complications and shorten the hospital stay by 1~3 days. Cryoablation is considered to be an ideal method for treating localized multiple tumors in the kidney.