Bullous dermatophytosis, also known as psoriasis, is not a contraindication to vaccination with the New Crown vaccine. Usually, patients can be vaccinated with the New Crown vaccine during the quiescent or receding phase; however, if in the acute or progressive phase, the vaccination needs to be administered after the skin disease has been controlled. Psoriasis is a common intractable skin disease with erythema and flaking as the main manifestation. The basic skin damage is erythematous or red papules covered with multiple layers of silvery white scales, mostly involving the whole body, especially on the scalp and extremities, which may manifest as pustules and erythroderma when the disease progresses. The main contraindication to vaccination with the new crown vaccine is the acute disease exacerbation period or chronic disease instability. Although psoriasis is a chronic disease, the New Crown vaccination needs to be withheld if the above symptoms are present during the onset of the disease. If there is a history of psoriasis in the past, but there is no onset and no other symptoms such as fever, allergy or other primary diseases are well controlled, it is possible to receive the New Crown vaccine. In addition to the clear contraindications to psoriasis and the New Crown vaccine, the above principles should also be followed before vaccination in the presence of other diseases in the body, and vaccination should not be given during acute attacks.