When chronic obstructive pulmonary cough aggravates at night, medication can be used, and oxygen therapy can be carried out in time, which can alleviate such phenomena. 1. medication: for the chronic obstructive pulmonary disease caused by night cough aggravation, you can take bronchodilators to effectively dilate the bronchial tubes, such as albuterol, formoterol, etc., so as to relieve respiratory obstruction or recurrent cough phenomenon. At the same time, when the cough is too violent, you can also take cough suppressants to relieve the irritation of the mucous membrane of the throat, such as codeine, dextromethorphan and so on. 2. Oxygen therapy: Because patients with chronic obstructive pulmonary disease may have different degrees of dyspnea and insufficient oxygen absorption in the process of breathing, which stimulates the recurrent symptoms of coughing at night. Therefore, appropriate oxygen therapy during the day or before bedtime can effectively meet the respiratory needs of the lungs. If the cough continues unabated, be alert to the possibility of a combined lung infection. Therefore, patients with COPD should be treated with appropriate medications under the guidance of a physician for any cough or other symptoms and should be reviewed regularly.