Membranous nephropathy legs no longer swollen is one of the signs of improvement, but not a sensitive sign of improvement, still need to be combined with 24-hour urine protein quantification, anti-PLA2R antibody and other comprehensive assessment. Membranous nephropathy is the main cause of adult nephrotic syndrome, which is characterized by proteinuria and edema. Large amounts of protein are lost from the urine, which in turn leads to hypoproteinemia, which causes edema. After standardized drug treatment, the urine protein decreases, so that the serum albumin rises, with the application of decongestive and diuretic drugs can make the lower limb edema reduce or subside, which is one of the signs of the improvement of the condition at this time. In addition, 24-hour urine protein quantification, renal function, anti-PLA2R antibody and other tests are also objective signs reflecting whether the condition has improved. It is important to note that patients with membranous nephropathy cannot stop taking the medication immediately when their legs are not swollen, otherwise their condition may recur or even worsen. Patients still need to take medication regularly, regular nephrological review, and must adjust the medication under the guidance of a professional physician.