Causes of acne around the mouth include acne, hand, foot and mouth disease, folliculitis, herpes simplex, etc. Treatment includes medication. 1. Acne: If acne is the cause of acne, it can be treated with medication such as fusidic acid cream or all-trans retinoic acid such as retinoic acid cream. 2. Hand, foot, and mouth disease: In the case of hand, foot, and mouth disease, no special treatment is usually needed. Symptoms such as fever, sore throat, and itching can be treated. 3. Folliculitis: If the folliculitis is caused by bacterial infection, you can give metronidazole, ofloxacin and other drugs antibacterial treatment. If the folliculitis is caused by fungus, it is recommended to give ketoconazole cream and other antifungal drugs. 4. Herpes simplex: If it is caused by herpes simplex virus infection, you can give antiviral treatment with valaciclovir. If you have acne around your mouth, please seek medical advice, and use the above medications under the guidance of a physician.