Cold and flu pain in the palate may be caused by a sore throat radiating to the palate due to an upper respiratory tract infection, which can be intervened with oral medications such as oseltamivir, acetaminophen, and dextromethorphan. 1. Anti-influenza virus drugs: Colds are mostly caused by viral infections and generally do not need to be treated with medication. For acquired immunodeficiency disease or influenza, oral antiviral drugs such as oseltamivir can be used. 2. Antipyretic and analgesic medications: These medications can be used to relieve symptoms of pain and fever, including acetaminophen and celecoxib. 3. Cough suppressants: severe coughing can irritate the mucous membranes of the mouth and pharynx, which may aggravate the pain symptoms. Codeine, dextromethorphan and other drugs can be used to suppress coughing, but it is important to note that codeine has a certain degree of addictiveness, and needs to be strictly evaluated after use, and long-term use of the drug is prohibited. Cold pain in the palate may also be a combination of diseases such as palate ulcers or acute tonsillitis. If the pain persists without relief, it is recommended to go to the hospital, complete the examination, clarify the cause of the disease, and follow the doctor’s instructions for treatment. The above mentioned drugs need to be used under the guidance of clinicians, and unauthorized use of drugs is prohibited.