There are many causes of spinal pain while sleeping, as the spine is a part of a wide range, from the cervical spine to the thoracic, lumbar and sacral spine. If the entire spine is painful while sleeping, the following two diseases are clinically considered: 1. Ankylosing spondylitis: influenced by genetic factors or occurring after exertion, it can lead to pain throughout the spine and can have spinal stiffness; 2. Rheumatoid arthritis: occurs when cold or without obvious triggers, leading to pain in small joints throughout the body, which includes the spinal joints. These two diseases are more likely, and it is recommended to go to a regular hospital to take blood tests to confirm the diagnosis and then treat the symptoms. In addition, patients with coronary artery disease can also manifest as spinal pain, but the symptoms are different from those of patients with conventional coronary artery disease, most of which are accompanied by conditions such as pain in the precordial region. Patients with duodenal ulcers and retrobulbar ulcers can also present with spinal pain. Patients are advised to always go to the hospital for relevant examinations, follow medical advice for medication, exercise appropriately daily, and choose a comfortable hard bed for rest.