There are still some people in life who suffer from cranial defects for various reasons. The skull is a very important organ in the human body, which plays an important role in protecting brain tissue and maintaining normal intracranial pressure. Once the skull is defective, it is necessary to undergo cranial repair surgery in a timely manner. In fact, in today’s developed medical environment, cranial repair is already a more routine surgery in neurosurgery, the operation is not complex, not very difficult, can be said that it is not a very big surgery. However, the material used for cranial bone repair is very important. Although the titanium mesh material widely used in clinical practice is much more advanced than other traditional materials, there are still many problems and complications, which affect the repair effect and limit the quality of life of the patients in the future. Cranial repair surgery is a relatively routine procedure in neurosurgery. It is a relatively short procedure with a short recovery period. From the time of diagnosis, to the surgery, to the time of discharge, the whole process is about half a month or so. This recovery, of course, is also related to the materials used for cranial repair. For example, the titanium mesh material, which is widely used in clinical practice today, has some problems. Postoperative may appear chronic pain, subcutaneous fluid accumulation, sensitive to hot and cold reaction, chronic cutting ulcers and other problems, but also affect the postoperative nuclear magnetic, CT and other medical examinations. Currently, a new type of PEEK material is clinically applied for cranial bone repair, and PEEK is also a good material that is currently recognized internationally as the standard for perfect cranial bone repair. the main components of PEEK are hyaluronic acid and Ebève, which have high biocompatibility and cause postoperative complications and foreign body reactions, which are basically absent in the clinic. the elasticity modulus of PEEK is better, and the bone plate made by printing with 3D technology can be printed before the operation. According to the patient’s monitoring data perfect three-dimensional molding, perfect restoration of the original structure of the skull.