The severity of thylakoid proliferative glomerulonephritis is related to the degree of renal pathological changes, clinical manifestations and sensitivity to treatment. Generally speaking, those with severe renal pathologic changes, severe clinical manifestations and insensitivity to treatment have a poorer and more serious prognosis. If the degree of renal pathologic changes is mild and the clinical manifestations are mild, after active treatment, the prognosis is still good and most of them are not serious. Mesangial proliferative glomerulonephritis is one of the pathological types of glomerulonephritis, and diffuse proliferation of glomerular mesangial cells and mesangial stroma can be seen in light microscopy, and the clinical manifestations can be asymptomatic proteinuria and/or hematuria, nephritis syndrome (hypertension, edema, hematuria, proteinuria, etc.), and nephrotic syndrome (hypoproteinemia, massive proteinuria, edema, hyperlipidemia, etc.). The prognosis is worse and more serious if there is hypertension, renal impairment, persistent proteinuria, pathological changes of severe tethered hyperplasia with sclerosis, and insensitivity to hormonal and other treatments. Patients with clinical manifestations of simple hematuria and mild pathological manifestations (mild thylakoid hyperplasia) respond well to treatment and have a better prognosis, which is mostly less serious, but some patients are prone to recurrence. Patients with thylakoid proliferative glomerulonephritis should go to the hospital in time and receive standardized treatment under the guidance of professional physicians.