Although Bolivar and aspirin both have the effect of inhibiting platelet aggregation, they differ in mechanism of action, indications, dosage, side effects and price. 1. Mechanism of action: Aspirin inhibits the synthesis of cyclooxygenase and thromboxane A2 to achieve the effect of anti-platelet aggregation, and all patients should take it for a long time if there is no contraindication to use it. Bolivar is a P2Y12 receptor inhibitor, which effectively reduces ADP-mediated platelet activation and aggregation by selectively and irreversibly inhibiting platelet adenosine diphosphate receptors and blocking ADP-dependent activation of the platelet membrane glycoprotein (GP) IIb/IIIa complex. In layman’s terms, it is like we can eat both steamed buns and rice in order to have a full stomach. 2. Indications: Aspirin: To prevent temporary ischemic attack (TIA), myocardial infarction, thrombosis after artificial heart valve, arteriovenous fistula or other surgery, also used for the treatment of unstable angina pectoris. Bolivar: It is used for the prevention and treatment of heart, brain and other arterial circulatory disorders caused by high platelet aggregation, such as recent onset of stroke, myocardial infarction and confirmed peripheral arterial disease, and is generally used in combination with aspirin to exert a dual antiplatelet effect. 3. Dosage: The optimal dose range of aspirin is 75-150mg/d (commonly used dose is 100mg/d). Bolivar is fast-acting and can reach the effective blood concentration 2-6 hours after taking 600mg, and 6-24 hours after taking 300mg. The commonly used maintenance dose is 75mg, taken orally once a day. 4, bleeding side effects: Although both aspirin and Bolivar can cause gastrointestinal tract injury and gastrointestinal bleeding, the latter has a lower chance of causing upper gastrointestinal tract injury and bleeding than aspirin. 5, price: Polivic and aspirin are quite expensive compared to each other in terms of price. Both Polivic and aspirin are anti-platelet aggregation drugs, and they both make the blood less likely to clot, which in turn prevents and controls diseases such as thrombosis. When applied alone, aspirin is used more often, and Polivir is more commonly used when applied in combination. It should be emphasized that both drugs need to be taken regularly under the guidance of a specialist.