Itchy perineal area needs to be considered in relation to poor lifestyle, contact dermatitis, pubic lice, etc. Treatment should be based on the cause and condition of the disease, such as applying drugs, internal drugs and oral medication. 1. Bad lifestyle: If the patient does not change underwear for a long time and does not wash the perineal area, it will lead to itching in the perineal area. This condition usually does not need medication, but should keep the area clean and hygienic. 2. Contact dermatitis: If the patient is allergic to sanitary napkins during menstruation, or allergic to the material of underwear, it will lead to itching in the perineal area. The patient should change the underwear and sanitary napkin, and can apply topical medicines such as Denadyl ointment, Tacrolimus ointment, etc., and take oral medicines such as Cetirizine Hydrochloride, Dicloretadine, etc. for treatment. 3. Pubic lice: If infected with pubic lice, there will also be obvious itching symptoms due to the bite of pubic lice, which needs to be treated by shaving the pubic hair and applying sulfur ointment. Considering that a variety of causes can lead to itchy perineal skin, it is recommended that patients consult a doctor in a timely manner, under the premise of clarifying the cause of the disease, and strictly comply with the doctor’s instructions for treatment.