Patients who have thigh pain when running for the first time may have strained muscles in the thigh area, affecting the normal lactic acid excretion in the local muscles, which will produce pain and swelling in the thigh area. The doctor can instruct the patient to stop running, rest in bed, or take a hot bath. You can also apply blood circulation and pain relief cream or golden ointment to the thigh area to promote the absorption of local bleeding, which can reduce the pressure in the muscle and stimulate the peripheral nerves, and then reduce the pain. In addition, you can also use oral medication for treatment, you can take oral ibuprofen extended-release tablets, hood forced and other drugs. In order to reduce the occurrence of the first running thigh pain, the patient can be instructed to do a good warm-up preparation before running, and after running need to do a good static stretching work.