Nausea and vomiting on a full stomach is considered to be caused by excessive intake, pyloric obstruction, dyspepsia and other diseases, which need to be improved by general treatment, medication and surgical treatment. 1. Excessive intake: If the diet is not regular, there is overeating and other bad eating habits, nausea and vomiting will occur. It is recommended to eat small meals and easy-to-digest foods. 2. Pyloric obstruction: If pyloric obstruction leads to nausea and vomiting on a full stomach, first of all, gastrointestinal decompression, during the symptomatic treatment, such as gastric acid secretion, follow the doctor’s instructions to take acid-suppressing drugs, such as omeprazole and so on. Oral pro-dynamic drugs, such as domperidone, etc., if the conservative treatment is ineffective, need to take surgical treatment to lift the obstruction, the surgical method of gastrojejunostomy, gastric resection and so on. 3. Indigestion: eating a full meal is always nausea and want to vomit may also be caused by indigestion, the patient should follow the doctor’s instructions to take gastrointestinal stimulating drugs, such as domperidone, mosapride, etc., if the upper abdominal distension after meals, you can follow the doctor’s instructions to take digestive enzymes, such as polypeptide, pancreatic enzyme tablets, etc.. There are many reasons for nausea and vomiting after eating a full meal, so it is recommended that the patient consult a doctor for a clear diagnosis and choose the appropriate treatment.