Routine doses of norfloxacin generally have no effect on normal kidney function. Patients with renal insufficiency need professional medical guidance for its use. Norfloxacin belongs to the quinolone antibiotics, is a broad-spectrum antibiotic, especially for gram-negative bacteria have a strong killing effect. Clinically, it is mainly used for the treatment of urinary tract, respiratory tract, gastrointestinal tract, skeletal system infections and prostatitis caused by sensitive bacteria, gonorrhea, typhoid fever, etc. It is also effective for mycoplasma and chlamydia infections. The main adverse reactions of norfloxacin are gastrointestinal reactions, such as abdominal pain, diarrhea, nausea or vomiting; central nervous system reactions, such as dizziness, headache, drowsiness or insomnia; allergic reactions. It should be noted that quinolones have an effect on the development of bones, especially long bones, and are therefore contraindicated in patients under 18 years of age. Norfloxacin is partially excreted by the kidneys, and patients with renal insufficiency should always use the drug cautiously under the guidance of a specialist and adjust the dosage according to the situation. If the patient has any discomfort, it is recommended to go to the regular hospital in time, and standardize the treatment under the guidance of the physician.