Urethral stinging pain brings discomfort to the patient and has a certain impact on life, which should be promptly diagnosed and treated in the hospital. Most of the urethral pain is caused by inflammation, including urethritis, cystitis, pyelonephritis, tuberculosis, prostatitis, etc., and should be treated for the specific cause of the disease, through sensitive antibiotics or anti-tuberculosis drugs for treatment. Most of them are treated with sensitive antibiotics empirically first, and if the results of urine culture plus drug sensitivity come out, effective treatment can be better targeted at bacteria, and if it is tuberculosis, anti-tuberculosis drugs can be added to the treatment. Patients in daily life should develop good habits and hygiene habits, especially women cystitis is caused by retrograde infection, before and after intercourse should wash the vulva, but also should drink more water, eat more vegetables, fruits and vegetables.