Lung puncture considered as poorly differentiated carcinoma with necrosis means that the mass is confirmed to be poorly differentiated carcinoma with extensive necrosis by pathological analysis after puncture biopsy, and it is a rapidly growing tumor. The degree of differentiation of cancer cells is usually divided into highly differentiated, moderately differentiated and lowly differentiated, in which highly differentiated cancer cells are closer to normal mature cells, which have relatively weaker metastatic ability and less invasive ability, and are more effective in treatment. On the other hand, poorly differentiated cancer cells, also called poorly differentiated cancer, are more similar to primitive cells, which have the strongest reproduction ability and differentiation ability, the highest degree of malignancy, and are most likely to metastasize and invade. Lung puncture is considered as poorly differentiated carcinoma with necrosis belongs to this type, and the condition of necrosis of cancer cells has already appeared, suggesting that the tumor is growing rapidly and the situation is more serious. When poorly differentiated carcinoma with necrosis occurs, patients need to seek medical treatment in time and actively treat the tumor, which is usually treated by surgery to remove the tumor and control its further development.