Toothpaste is basically useless when you have a toothache, mainly due to the following reasons: firstly, toothache can be caused by a variety of reasons, and in the case of caries or pulpitis, cavity repair as well as root canal treatment is required. Toothpaste, if applied locally to the lesion, will not have any antiseptic or disinfectant effect and therefore will not have any effect on the pain. Secondly, if the toothache is caused by a tumor in the jawbone, applying toothpaste on the gums or the surface of the teeth will not have any effect, and the only way to stop the pain is to perform surgery to remove the tumor. But when the toothache can take other commonly used methods, such as the peppercorns bite in the part of the toothache, peppercorns itself has a certain anesthetic effect, can make the teeth of the nerves undergo temporary anesthesia, so that the pain relief.