Neuronal intranuclear inclusion bodies refers to the typical pathologic manifestations of central nervous system neurons in patients with neuronal intranuclear inclusion body disease. Neuronal nuclear inclusion body disease is a rare hereditary neurodegenerative disease in which patients often have symptoms of central and peripheral nervous system damage, such as numbness and weakness of the limbs, episodes of impaired consciousness, ataxia, and defecation disorders. The symptoms are complex and the diagnosis of the disease used to be based on autopsy. In recent years, there has been an increase in imaging, genetic testing, and dermatologic pathology, which is expected to improve the diagnostic accuracy of the disease. Like most hereditary diseases, there is no effective treatment for this disease, and the main treatment is symptomatic. If the patient is not feeling well, it is recommended to consult a doctor in time and under the guidance of a professional doctor for standardized diagnosis and treatment.