Whether acute kidney injury can be self-healed mainly depends on its etiology. If pre-renal factors such as diarrhea cause acute kidney injury, when the diarrhea stops and normal diet is resumed, blood volume is restored, and then it is possible to recover spontaneously; if renal factors such as tubular epithelial cell necrosis or interstitial nephritis, and post-renal factors such as urinary tract obstruction cause acute kidney injury, it is usually not possible to recover spontaneously. Acute kidney injury can be categorized into three main groups, pre-renal, renal and post-renal, according to the anatomical site where the etiology occurs. Pre-renal factors such as diarrhea and dehydration caused by acute kidney injury, after the diarrhea stops, the patient resumes a normal diet, the lost water may be gradually replaced, blood volume recovery, at this time the acute kidney injury may be self-healing. However, acute kidney injury caused by renal factors such as tubular epithelial cell necrosis or interstitial nephritis, and post-renal factors such as urinary tract obstruction, usually need to remove the cause of acute kidney injury through treatment before curing acute kidney injury, which can not be cured by itself at this time. Patients with acute kidney injury are recommended to go to regular hospitals for timely consultation, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of doctors.