Osteoarthritis of ankle can be treated by medication, surgery and exercise therapy. 1. Drug treatment: Osteoarthritis drug treatment is divided into local drug treatment and systemic drug treatment, local drug treatment mainly uses non-steroidal anti-inflammatory drugs for topical treatment, and systemic drug treatment is carried out through oral administration of non-steroidal anti-inflammatory drugs such as Indomethacin, Etoricoxib, and other cartilage protection agents such as bisacodyl Ruijin and Glucosamine Hydrochloride, and other drugs. 2. Surgery: Osteoarthritis patients with long-term pain can undergo surgery such as joint fusion, articular cartilage repair, arthroscopic cleaning and other surgical treatments. 3. Exercise therapy: Osteoarthritis patients can do muscle training, resistance training, passive joint movement and other exercises to enhance the stability of joints and promote local blood circulation. Drugs should be used under the guidance of a physician, and it is recommended that patients go to the orthopedics and rheumatology departments of regular hospitals for detailed consultation and treatment as prescribed.