Side effects such as fever, cough, dyspnea, allergic reactions, elevated liver enzymes, and jaundice may occur in a 9-year-old girl injected with leuprolide.
According to the drug insert, leuprolide is indicated for the treatment of endometriosis, uterine fibroids, prostate cancer, and estrogen receptor-positive premenopausal breast cancer in adults, as well as for the treatment of central precocious puberty in children. Common adverse reactions include fever, cough, interstitial pneumonitis, elevated liver enzymes, and jaundice.
Leuprolide is contraindicated in people who are allergic to the components of the drug, pregnant and lactating women, and people with vaginal bleeding of unknown nature.
Central precocious puberty refers to a common pediatric endocrine disease in which the rapid development of internal and external genital organs and the appearance of secondary sexual characteristics occur before the age of 8 years in girls and before the age of 9 years in boys due to the early activation of the function of the hypothalamic-pituitary-gonadal axis. Leuprorelin may delay excessive skeletal maturation and improve final adult height.
Leuprolide is clinically indicated for the treatment of central precocious puberty, with precise efficacy, but the adverse effects should not be ignored, and need to be strictly under the guidance of the doctor and monitoring of drug treatment.