Glimepiride belongs to a kind of glucose-lowering drug that promotes insulin secretion, and taking the drug may lead to hypoglycemia, which in itself does not harm the pancreas. However, because it promotes insulin secretion, it may be less effective in lowering glucose for people whose pancreas itself is not functioning well. Adverse effects of glimepiride include hypoglycemia, dizziness, weakness, headache, and nausea. It is possible to cause hypoglycemia in the process of lowering sugar, which is harmful to the body. Especially for the elderly or people with combined cardiovascular and cerebrovascular diseases, hypoglycemia should be avoided. Therefore, the use of the drug should start from a small dose, cooperate with the doctor, follow the doctor’s instructions, monitor the changes in blood glucose during the application, and adjust the dose of the drug in a timely manner.