It is normal to have a red rash after receiving the HFMD vaccine. A mild transient rash is an adverse reaction and can be treated with localized warm compresses; if it continues to worsen with other symptoms, it may be caused by allergy, which is abnormal and requires prompt medical attention. After the hand-foot-mouth vaccination, the localized red rash is a normal adverse reaction caused by the vaccine, but this kind of adverse reaction is generally self-limiting, usually to a lesser extent, and does not require treatment, it can be self-healing. Localized hot compresses can be applied to promote blood circulation to help recovery. However, if the scope of the rash continues to expand, or accompanied by pain, itching and other symptoms, may be caused by allergies, which is not normal, especially when there are respiratory difficulties, lip edema and other symptoms, do not delay, need to consult a doctor for treatment in a timely manner, according to the doctor’s advice to deal with can be.