Patient: advanced stage 3 gastric cancer with extensive implantation spread to the abdominal pancreas without surgery. 1. chemotherapy regimen without surgery was 5-fu750mg plus oxaliplatin 2. indicators before chemotherapy were normal the day immediately after the second chemotherapy was finished leukocytes dropped to 2200 other indicators were basically normal range. 2, after chemotherapy patient severe constipation 1. whether to play white injection immediately? Or after seven days? How to control the dose and frequency? What can be done? 3. Is it necessary to change the regimen for the next chemotherapy? What about the Hirona plus oxaliplatin regimen? 4. How to cooperate with the addition of other adjuvant therapy? Doctor: The whitening injection is usually available 24-72 hours after chemotherapy. Your current situation is basically 200 micrograms a day for two consecutive days and then review your blood work. Constipation may be a side effect of 5-FU, some people show diarrhea, some people constipation varies from person to person. It may also be caused by the neurotoxicity of oxaliplatin regimen. You can take it with senna leaf during chemotherapy. It’s not necessary to change the program, the Hierroda program is more convenient, the efficacy is not better than the current. The side effects also depend on individual circumstances. You can use some liver protection and neurotropic drugs, antiemetic drugs do not use too strong, may aggravate constipation.