Total bilirubin of 300μmol/L does not need artificial liver. Artificial liver refers to the treatment method of removing harmful substances from the body through mechanical, physical, chemical or biological devices outside the body, supplementing essential substances to maintain the stability of the internal environment, and temporarily replacing part of the function of the failing liver. Artificial liver treatment is needed only when the patient’s condition develops to severe liver insufficiency and liver failure. If the total bilirubin increases to 300μmol/L, the cholestasis is more serious, but it does not mean that the patient has liver failure, and it is necessary to evaluate the condition together with clinical symptoms and laboratory tests to determine whether there are bile duct stones, bile duct stenosis and bile duct tumors, etc., and carry out the treatment under the guidance of the clinician. Total bilirubin of 300μmol/L does not require artificial liver treatment, and it is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease, so as to avoid delaying the condition.