Nipple pain can be caused by physiological factors and usually does not require special treatment. It may also be caused by breast hyperplasia or nipple inflammation, which can be relieved by taking medication according to different situations. 1. Physiological factors: pre-menstrual period due to estrogen and progesterone elevated stimulation of breasts, may cause nipple pain, belong to the physiological reaction of pre-menstrual period, the patient does not need to do special treatment, after menstruation will be recovered on its own. 2. Mammary hyperplasia: Mammary hyperplasia is a relatively common benign breast disease in women, mostly caused by endocrine dysfunction. The main symptom is pain in the breast area, nipple pain is also common. Under the guidance of the doctor, you can take medication such as free pills for treatment, which can effectively relieve the symptoms. 3. Nipple inflammation: commonly caused by bacteria entering the local tissue through the wound after nipple trauma, when the inflammation is serious, nipple pain may occur. It can be treated with medication, commonly used drugs are ofloxacin ointment and fusidic acid cream, which can effectively reduce inflammation and relieve pain. When nipple pain occurs, it is recommended to consult a doctor to identify the cause of the problem and carry out targeted treatment or therapy.