The most serious complication of urinary stones can be uremia, which is most often seen in bilateral urinary stones, such as bilateral kidney stones, ureteral stones or huge kidney stones, but also urethral stones. All of these stones can lead to severe hydronephrosis. When the hydronephrosis develops to the final degree it can lead to the decline of kidney function and the manifestation of uremia, but this condition is often caused by prolonged delay without treatment and management. If timely treatment will not develop to the stage of uremia, because the stone is a curable disease, not a malignant tumor can not be cured. When suffering from stones, medication, extracorporeal shock wave lithotripsy or surgical treatment is needed to expel stones from the body as soon as possible, the obstruction caused by stones will disappear, and urine produced by the kidneys can be smoothly discharged into the bladder without hydronephrosis. However, if the stone stays in the body for a long time, part of the urine produced by the kidneys will be discharged from the body, and the other part will stay in the kidneys because of the stone obstruction, which will lead to the decline of renal function in the long run and uremia will occur.