Delayed pubertal development, in addition to the backward development of secondary sexual characteristics, generally have other corresponding physical characteristics, girls also need to observe the backwardness of the bone age, detailed questioning of the family history, to see whether there is excessive elbow ectropion, neck webbing, shield chest and other clinical manifestations, to be differentiated. Similarly, boys with delayed puberty need to be looked at for signs of feminization, lagging testicular development, excessive obesity, or physical characteristics such as mammary gland development to make a differential diagnosis. Delayed pubertal development can be caused by disease or a physiological phenomenon in the process of pubertal development, and its manifestations are not specific, so it is necessary to determine the specific causes according to the auxiliary examination indicators.