Skin ulceration after radiotherapy for breast cancer should immediately stop radiotherapy, saline or povidone-iodine solution for local rinsing, application of antibiotic ointment and so on. If skin ulceration occurs after radiotherapy for breast cancer patients, it should be considered as radiation dermatitis, and secondary infection may occur if it is serious, radiotherapy should be stopped immediately to avoid aggravation of the condition, and relevant laboratory tests and examinations should be carried out, etc., because bone marrow suppression is easy to be complicated during or after radiotherapy. For skin ulceration after radiotherapy for breast cancer, saline can be used for local rinsing, or iodophor solution can be diluted and sterilized every day to keep the local dryness, and antibiotic ointment such as erythromycin ointment, mupirocin ointment can be applied, and the symptom can be improved gradually. After breast cancer radiotherapy skin ulcers should pay attention to supplemental nutrition, appropriate supplementation of protein-rich food.