There are several possible scenarios for a positive hepatitis C antibody: 1. Previously infected with the hepatitis C virus: The patient has not been treated with interferon antiviral therapy and is positive for hepatitis C antibody, but is negative for HCV-RNA and normal for transaminases and other indicators. At this time, positive hepatitis C antibody only means that they have been infected with hepatitis C virus and have been cured. 2, hepatitis C patients: hepatitis C antibody positive, while HCV-RNA positive, regardless of whether the liver function is abnormal, the patient can be judged to have hepatitis C, if there is no contraindication, should be interferon antiviral therapy. 3, patients with autoimmune hepatitis, may also appear positive hepatitis C antibodies, at this time can not simply according to the positive hepatitis C antibodies to indicate that the patient has hepatitis C, can further check the relevant indicators of the immune system. 4, false positive: rheumatoid factor (RF) interference, hyperimmunoglobulinemia and other conditions can also appear positive hepatitis C antibody, should be combined with the epidemiological history and HCV RNA to determine whether hepatitis C patients. Therefore, a single positive hepatitis C antibody should not be used to determine whether a patient has hepatitis C. A careful history should be taken and further tests should be performed to determine this. Changes in the ratio of hepatitis C antibody indicators do not indicate the severity of the disease. Lin Chaoshuang, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University As to whether treatment is needed, it needs to be judged in conjunction with HCV RNA.