After surgery for stage III gastric cancer, targeted drug therapy is usually not used, and postoperative adjuvant therapy is needed according to the surgery. Stage III gastric cancer staging is relatively late, if the surgery can reach complete resection, postoperative adjuvant chemotherapy can be considered, and generally two-drug combination regimen is used, such as oxaliplatin, tiglio and so on. If the surgery can not achieve complete resection of gastric cancer stage III, with tumor residue after surgery, the adjuvant treatment with combination of radiotherapy and chemotherapy is needed. Targeted drugs are generally used in the treatment of advanced metastatic gastric cancer, and the corresponding targeted drugs are selected according to the results of immunohistochemistry and genetic test of gastric cancer, among which Apatinib, trastuzumab and so on are commonly used drugs. Therefore, the treatment for stage III gastric cancer after surgery should be chosen according to the postoperative pathology, immunity and gene test results, and should be reviewed regularly.