Earlier applied more NSAIDs, such as acetylsalicylic acid, POTUS, etc. often have serious gastrointestinal reactions, mainly manifested as epigastric discomfort, dyspepsia, acid reflux, heartburn, nausea, vomiting, and even gastrointestinal bleeding, perforation and other emergencies. Sometimes uncontrollable hemorrhage or even life-threatening occurs without any aura. Although the currently used NSAIDs are relatively safe, the occurrence of these conditions still cannot be completely excluded. Patients with previous history of gastric ulcer, duodenal ulcer and gastritis, and those with recent gastric symptoms are advised not to use NSAIDs. If – they must be used, they should be explained to the physician in advance and used with care under guidance. If black stools and vomiting of blood occur, the drug should be discontinued immediately and medical attention should be sought promptly to prevent aggravation of the condition. Other patients should try to take it after meals when applying to reduce the irritation to the gastrointestinal mucosa. If you feel uncomfortable with one NSAID, you can switch to other similar drugs under the advice of your physician. The simultaneous use of two or more NSAIDs can not enhance the efficacy, but can aggravate the side effects. In order to reduce the reaction of the digestive tract, enteric tablets or drugs to protect the gastric mucosa, such as acidophilus, cimetidine, misoprostol, etc., and smoking, alcohol, coffee and other stimulating foods should be abstained.