High-energy targeted radiodynamic therapy (MTRT for short) is a new method to take advantage of the different affinity and metabolism rates of tumor cells and normal cells for photosensitizers, when the patient orally takes photosensitizers (modified porphyrins) and then absorbed into the tumor lesion, and then irradiated by low-dose high-energy X-rays of 45MV through LA45, which generates sufficient amount of oxygen radicals and kills the cancer cells in any part of the body through molecular targeting. This advanced technology can be imaginatively called “photon missile”, which is guided and detonated by photosensitive drugs to kill and remove cancer cells in a targeted and accurate manner.LA45 high-energy targeted power therapy integrates the advantages of chemotherapy, targeted therapy and radiation therapy, which greatly improves the therapeutic effect and at the same time reduces the negative effects and adverse reactions of these therapeutic modes. MTRT has achieved amazing results in treating cancer, especially in treating advanced cancer patients with recurrence and metastasis! Technical principle: Using the high affinity effect of photosensitive drug (modified porphyrin) on cancer cells (the concentration in cancer cells can be 10-20 times higher than that in normal cells), as well as the molecular targeting effect (binding to the key target molecules), the tumor foci are accurately localized through the advanced biomolecular imaging technology. Then, high-energy photons are used to stimulate the photosensitive drug at a fixed point on the target molecules of the lesion cells, which produces a conformational change and catalyzes the formation of a single linear state of oxygen (1O2) from the oxygen-containing substrate. Low-dose high-energy photons, photosensitive drugs and catalytic substrates have no obvious toxicity, but the product produced by the three actions —- single-line oxygen (1O2) has a powerful cell destruction effect, which can destroy the biological target molecules and kill the cancer cells within the range of <20nm around the photosensitive drugs. Therapeutic features and advantages: 1. It has the basic effect of X-ray radiotherapy: 25% of the effect is that X-ray directly kills the DNA terminals of cancer cells, and 75% of the effect is that X-ray generates hydroxyl radicals, which destroys the DNA terminals of cancer cells. 2.With the basic role of photodynamic therapy: 45MV X-ray enters into the body and generates light between tissues (Cherenkov effect ). Light can increase the electric quadrupole effect of coenzyme and 45MV X-ray photonuclear reaction. 3, great killing power of lesion cells: molecular targeting point acts on the starting point of apoptosis and necrosis program of tumor cells, which can rapidly lead to tumor cell death. 4.Good targeting: it has molecular targeting effect, has the characteristics of targeted drugs, and has strong affinity effect on cancer cells and no toxic effect on surrounding normal cells. It has strong affinity to cancer cells and has no toxic effect on the surrounding normal cells, so it has very little side effect at the same time of high therapeutic effect. 5. Solve the problem of easy repair of injured DNA end position in conventional radiotherapy: light, photosensitizer and oxygen produce monomorphic oxygen, which damages the mitochondrial membrane and causes the death or apoptosis of cancer cells. 6. Solve the problem of cancer treatment in which the cancer cells are insensitive to lack of oxygen: 45MV X-ray excites the water in the body to produce hydrogen peroxide, and light, photosensitizer and hydrogen peroxide produce singlet oxygen, which can damage the mitochondrial membrane and cause the death or apoptosis of the cancer cells under the state of lack of oxygen or lack of oxygen in the cancer cells. 7. Solve the problem of tumor lesions having less drug absorption because of ischemia: 4 hours after taking the drug, each time of local appropriate treatment, the X-ray radiation is 5-8GY, even if the concentration of the drug is reduced by 100 times, enough oxygen radicals can be obtained. 8, for local and systemic lesions are effective: due to the simultaneous systemic effect of drug therapy (chemotherapy) and radiation therapy (radiotherapy) of the local role, so that the advantages of the two therapeutic effects to give full play to the effect of 1 + 1 is greater than 2, but also greatly reduce each other's side effects. 9, small side effects: the use of oral amino acids as a means of synthesizing photosensitizers in vivo, amino acids itself is non-toxic, without the systemic toxic effects of chemotherapeutic drugs. 10, the use of very low total dose of high-energy photons (4-5Gy) excitation, absorbed dose in the conventional radiation therapy below 1/10, and thus there will be no radiotherapy side effects and complications. 11, short treatment cycle, can be repeatedly applied. 12.Wide range of indications:, it can treat most of the middle and late malignant tumors in the whole body. Indications: It is clinically applicable to the treatment of most tumors in the whole body. It mainly includes the following: l Neurological system tumors: including all kinds of primary and metastatic brain tumors, spinal cord tumors, thalamus tumors, medulloblastoma, glioblastoma, choroidal papilloma, AVM, trigeminal neuralgia, etc.; l Head and neck tumors: including nasopharyngeal carcinoma, paranasal sinus carcinoma, oropharyngeal carcinoma, tonsillar carcinoma, oral cavity tumors, salivary gland carcinoma, thyroid carcinoma, etc.; l Thoracic tumors: including breast carcinoma, esophageal cancer, lung cancer, thymoma, thyroid cancer, thyroid carcinoma, etc. l Abdominal and pelvic tumors: including hepatocellular carcinoma, pancreatic carcinoma, gallbladder carcinoma, bile duct carcinoma, retroperitoneal tumor, renal carcinoma, cervical carcinoma, uterine body carcinoma, rectal carcinoma, bladder carcinoma, prostate carcinoma, etc. Treatment: 1), whole-body microdosage irradiation: LD: 10-15 cGy/fx, f/w*4-6f, DTtol: 40-90 cGy. 2), whole-body microdosage irradiation: LD: 10-15 cGy/fx, f/w*4-6f, DTtol: 40-90 cGy. 90 cGy. 2), local area: local multi-focal metastasis and it is not easy to carry out localized focal conformal treatment area: 2Gy/f,qod(f/w)*6~4f, DTtol:6-12Gy. 3), localized foci: another target area can be set up: 3~8Gy/f,qod(f/w)*6~4f, DTtol:16~30Gy. 4), treatment Interval: once a week in general. Total 3-6 times.