High bilirubin on febuxostat may be an adverse reaction to the medication, or it may be considered to be caused by a liver or gallbladder disease. If necessary, you can change the medication or go to the hospital for examination and treatment for the primary disease. 1. Adverse drug reactions: febuxostat is a western drug belonging to the anti-gout, mainly used for long-term treatment of hyperuricemia. In addition to treating the disease, the drug may also have some adverse reactions, such as liver function abnormalities, increased bilirubin and so on. High bilirubin during taking febuxostat, sure that it is caused by adverse drug reactions, it is recommended to go to the rheumatology and immunology department of the hospital for examination, which can be combined with the doctor’s opinion, and if necessary, replace other drugs for treatment, such as benzbromarone, probenecid, allopurinol, uric acid enzyme and so on. 2. Hepatobiliary diseases: for example, biliary tract obstruction after cirrhosis, which is prone to high bilirubin. Most patients with biliary tract obstruction need to receive surgical treatment, such as low biliary tract obstruction, obstruction near duodenal papilla, which can be treated by surgical release of obstruction. To summarize, taking febuxostat with high bilirubin is recommended to draw attention to, it is recommended to go to the hospital for examination, to clarify the cause of the disease, and follow the doctor’s instructions for treatment.