Coughing up yellow sputum and yellow nasal discharge, the clinical manifestation is mainly respiratory tract with bacterial infection, mainly purulent bacterial infection, such as Staphylococcus aureus. At this time, you can usually take antibiotics appropriately, preferred such as penicillin drugs, if necessary, you can also choose to take amoxicillin, cloxacillin, piperacillin and so on. If the bacteria are resistant to the drug, you can choose amoxicillin clavulanate potassium, cefuroxime sodium, ceftriaxone sodium, cefoperazone sulbactam sodium, but also can be used in combination with the use of clindamycin, erythromycin, azithromycin, as well as levofloxacin and other drugs.